Effect of Helicobacter Pylori Infection on Iron Profile Among Patients Attending Kosti Teaching Hospital, Sudan

الملخص

Background: As approved by many studies patients with H. pylori infection; a spiral bacterium that invade
different parts of gastrointestinal tract and mainly gastric mucosa causing gastric inflammation and peptic
ulceration may linked directly to body iron status.
This study aimed to evaluate the body iron status in H .pylori infected patients
Methods: This study was conducted in Kosti Teaching Hospital, White Nile State (Sudan) Jan 2018 to March
2019. The study groups consisted of 58 patients with H. pylori as cases group and another group were 58 healthy
subjects as the control group. The members of both groups were enrolled in the study voluntarily. Study groups
demographic and anthropometric data, hemoglobin, serum ferritin and total iron- binding capacity and transferrin
were measured.
Results: Hemoglobin, serum ferritin (11.32 vs. 79.15 ng/ml) was significantly lower when compared with the
control one. On other hand transferrin and total iron-binding capacity statistically reflected higher figures as
(397.05 vs. 265.11 mg/dl) and (543.21 vs.270.42 mcg/dl) respectively when compared case group with control
one. Moreover endoscopy screening of patients reflected considerable information regarding esophagitis, gastritis,
duodenal ulcer and esophageal cancer.
Conclusion: Although the findings of present study revealed that H. pylori are able to interfere with the
distribution of biological iron, reflecting significant alteration on parameters related to iron homeostasis. Since
evidence for the association of H. pylori and IDA still not enough and there are contrasting data about such
association, future high quality and cohort researches are needed to determine the causal association.